NKAIN3-WRN Fusion FISH Probe
The NKAIN3-WRN Fusion FISH Probe is used to confirm a fusion of the NKAIN3 and WRN genes. The fusion of the NKAIN3 and WRN genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NKAIN3-WRN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-RERE | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-REOR | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-REGO | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-REGR | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-REAQ | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-ORRE | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-OROR | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-ORGO | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-ORAQ | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-GORE | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-GOOR | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-GOGO | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-GOGR | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-GOAQ | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-GRRE | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-GROR | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-GRGO | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-GRGR | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-GRAQ | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-AQRE | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-AQOR | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-AQGO | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-AQGR | 20 (40 μL) | 200 μL |
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| NKAIN3-WRN-20-AQAQ | 20 (40 μL) | 200 μL |
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WRN Gene Summary
This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]
Gene Name: Werner Syndrome RecQ Like Helicase
Chromosome: CHR8: 30890777 -31031277
Locus: 8p12
NKAIN3 Gene Summary
NKAIN3 is a member of a family of mammalian proteins (see NKAIN1; MIM 612871) with similarity to Drosophila Nkain (Gorokhova et al., 2007 [PubMed 17606467]).[supplied by OMIM, Jun 2009]
Gene Name: Sodium/potassium Transporting ATPase Interacting 3
Chromosome: CHR8: 63161500 -63903628
Locus: 8q12.3
Gene Diseases
The NKAIN3 WRN Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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