NISCH-PBRM1 Fusion FISH Probe
The NISCH-PBRM1 Fusion FISH Probe is used to confirm a fusion of the NISCH and PBRM1 genes. The fusion of the NISCH and PBRM1 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NISCH-PBRM1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-RERE | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-REOR | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-REGO | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-REGR | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-REAQ | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-ORRE | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-OROR | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-ORGO | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-GORE | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-GOOR | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-GOGO | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-GOGR | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-GRRE | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-GROR | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-GRGO | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-GRGR | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-AQRE | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-AQOR | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-AQGO | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-AQGR | 20 (40 μL) | 200 μL |
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| NISCH-PBRM1-20-AQAQ | 20 (40 μL) | 200 μL |
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NISCH Gene Summary
This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013]
Gene Name: Nischarin
Chromosome: CHR3: 52489523 -52527088
Locus: 3p21.1
PBRM1 Gene Summary
This locus encodes a subunit of ATP-dependent chromatin-remodeling complexes. The encoded protein has been identified as in integral component of complexes necessary for ligand-dependent transcriptional activation by nuclear hormone receptors. Mutations at this locus have been associated with primary clear cell renal cell carcinoma. [provided by RefSeq, Feb 2012]
Gene Name: Polybromo 1
Chromosome: CHR3: 52579367 -52719866
Locus: 3p21.1
Gene Diseases
The NISCH PBRM1 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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