NISCH-DNAH1 Fusion FISH Probe
The NISCH-DNAH1 Fusion FISH Probe is used to confirm a fusion of the NISCH and DNAH1 genes. The fusion of the NISCH and DNAH1 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NISCH-DNAH1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-RERE | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-REOR | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-REGO | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-REGR | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-REAQ | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-ORRE | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-OROR | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-ORGO | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-GORE | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-GOOR | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-GOGO | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-GOGR | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-GRRE | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-GROR | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-GRGO | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-GRGR | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-AQRE | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-AQOR | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-AQGO | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-AQGR | 20 (40 μL) | 200 μL |
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| NISCH-DNAH1-20-AQAQ | 20 (40 μL) | 200 μL |
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NISCH Gene Summary
This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the cytosol and anchors to the inner layer of the plasma membrane. The orthologous mouse protein has been shown to influence cytoskeletal organization and cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to endosomes. Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation. Alternative splicing results in multiple transcript variants encoding differerent isoforms. Some isoforms lack the expected C-terminal domains of a functional imidazoline receptor. [provided by RefSeq, Jan 2013]
Gene Name: Nischarin
Chromosome: CHR3: 52489523 -52527088
Locus: 3p21.1
DNAH1 Gene Summary
This gene encodes an inner dynein arm heavy chain that provides structural support between the radial spokes and the outer doublet of the sperm tail. Naturally occurring mutations in this gene are associated with primary ciliary dyskinesia and multiple morphological anomalies of the flagella that result in asthenozoospermia and male infertility. Mice with a homozygous knockout of the orthologous gene are viable but have reduced sperm motility and are infertile. [provided by RefSeq, Feb 2017]
Gene Name: Dynein Axonemal Heavy Chain 1
Chromosome: CHR3: 52350334 -52434513
Locus: 3p21.1
Gene Diseases
The NISCH DNAH1 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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