NIPBL-STK24 Fusion FISH Probe
The NIPBL-STK24 Fusion FISH Probe is used to confirm a fusion of the NIPBL and STK24 genes. The fusion of the NIPBL and STK24 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NIPBL-STK24-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-RERE | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-REOR | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-REGO | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-REGR | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-REAQ | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-ORRE | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-OROR | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-ORGO | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-ORAQ | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-GORE | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-GOOR | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-GOGO | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-GOGR | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-GOAQ | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-GRRE | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-GROR | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-GRGO | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-GRGR | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-GRAQ | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-AQRE | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-AQOR | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-AQGO | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-AQGR | 20 (40 μL) | 200 μL |
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| NIPBL-STK24-20-AQAQ | 20 (40 μL) | 200 μL |
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STK24 Gene Summary
This gene encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the N-terminal fragment (MST3/N) translocates to the nucleus and promotes programmed cells death. There is a pseudogene for this gene on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Gene Name: Serine/threonine Kinase 24
Chromosome: CHR13: 99102454 -99229396
Locus: 13q32.2
NIPBL Gene Summary
This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: NIPBL, Cohesin Loading Factor
Chromosome: CHR5: 36876860 -37065921
Locus: 5p13.2
Gene Diseases
The NIPBL STK24 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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