NIPBL-NACC1 Fusion FISH Probe
The NIPBL-NACC1 Fusion FISH Probe is used to confirm a fusion of the NIPBL and NACC1 genes. The fusion of the NIPBL and NACC1 genes has been associated with Cholangiocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NIPBL-NACC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-RERE | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-REOR | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-REGO | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-REGR | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-REAQ | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-ORRE | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-OROR | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-ORGO | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-GORE | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-GOOR | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-GOGO | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-GOGR | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-GRRE | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-GROR | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-GRGO | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-GRGR | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-AQRE | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-AQOR | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-AQGO | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-AQGR | 20 (40 μL) | 200 μL |
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| NIPBL-NACC1-20-AQAQ | 20 (40 μL) | 200 μL |
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NIPBL Gene Summary
This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: NIPBL, Cohesin Loading Factor
Chromosome: CHR5: 36876860 -37065921
Locus: 5p13.2
NACC1 Gene Summary
This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Feb 2012]
Gene Name: Nucleus Accumbens Associated 1
Chromosome: CHR19: 13229108 -13251959
Locus: 19p13.13
Gene Diseases
The NIPBL NACC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Cholangiocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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