NIPBL-MRPS30 Fusion FISH Probe
The NIPBL-MRPS30 Fusion FISH Probe is used to confirm a fusion of the NIPBL and MRPS30 genes. The fusion of the NIPBL and MRPS30 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NIPBL-MRPS30-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-RERE | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-REOR | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-REGO | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-REGR | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-REAQ | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-ORRE | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-OROR | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-ORGO | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-ORAQ | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-GORE | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-GOOR | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-GOGO | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-GOGR | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-GOAQ | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-GRRE | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-GROR | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-GRGO | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-GRGR | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-GRAQ | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-AQRE | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-AQOR | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-AQGO | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-AQGR | 20 (40 μL) | 200 μL |
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| NIPBL-MRPS30-20-AQAQ | 20 (40 μL) | 200 μL |
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MRPS30 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available. [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Ribosomal Protein S30
Chromosome: CHR5: 44809026 -44815618
Locus: 5p12
NIPBL Gene Summary
This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: NIPBL, Cohesin Loading Factor
Chromosome: CHR5: 36876860 -37065921
Locus: 5p13.2
Gene Diseases
The NIPBL MRPS30 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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