NIPBL-MAPRE1 Fusion FISH Probe
The NIPBL-MAPRE1 Fusion FISH Probe is used to confirm a fusion of the NIPBL and MAPRE1 genes. The fusion of the NIPBL and MAPRE1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NIPBL-MAPRE1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-RERE | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-REOR | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-REGO | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-REGR | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-REAQ | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-ORRE | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-OROR | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-ORGO | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-GORE | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-GOOR | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-GOGO | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-GOGR | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-GRRE | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-GROR | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-GRGO | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-GRGR | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-AQRE | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-AQOR | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-AQGO | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-AQGR | 20 (40 μL) | 200 μL |
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| NIPBL-MAPRE1-20-AQAQ | 20 (40 μL) | 200 μL |
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MAPRE1 Gene Summary
The protein encoded by this gene was first identified by its binding to the APC protein which is often mutated in familial and sporadic forms of colorectal cancer. This protein localizes to microtubules, especially the growing ends, in interphase cells. During mitosis, the protein is associated with the centrosomes and spindle microtubules. The protein also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. Because of these associations, it is thought that this protein is involved in the regulation of microtubule structures and chromosome stability. This gene is a member of the RP/EB family. [provided by RefSeq, Jul 2008]
Gene Name: Microtubule Associated Protein RP/EB Family Member 1
Chromosome: CHR20: 31407698 -31438211
Locus: 20q11.21
NIPBL Gene Summary
This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: NIPBL, Cohesin Loading Factor
Chromosome: CHR5: 36876860 -37065921
Locus: 5p13.2
Gene Diseases
The NIPBL MAPRE1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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