NIPBL-FGF10 Fusion FISH Probe
The NIPBL-FGF10 Fusion FISH Probe is used to confirm a fusion of the NIPBL and FGF10 genes. The fusion of the NIPBL and FGF10 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| NIPBL-FGF10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-RERE | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-REOR | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-REGO | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-REGR | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-OROR | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-GORE | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-GROR | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| NIPBL-FGF10-20-AQAQ | 20 (40 μL) | 200 μL |
|
FGF10 Gene Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]
Gene Name: Fibroblast Growth Factor 10
Chromosome: CHR5: 44305096 -44388784
Locus: 5p12
NIPBL Gene Summary
This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: NIPBL, Cohesin Loading Factor
Chromosome: CHR5: 36876860 -37065921
Locus: 5p13.2
Gene Diseases
The NIPBL FGF10 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|