NIPBL-ARNTL2 Fusion FISH Probe
The NIPBL-ARNTL2 Fusion FISH Probe is used to confirm a fusion of the NIPBL and ARNTL2 genes. The fusion of the NIPBL and ARNTL2 genes has been associated with Rectum Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NIPBL-ARNTL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-RERE | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-REOR | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-REGO | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-REGR | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-REAQ | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-ORRE | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-OROR | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-ORGO | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-GORE | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-GOOR | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-GOGO | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-GOGR | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-GRRE | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-GROR | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-GRGO | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-GRGR | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-AQRE | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-AQOR | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-AQGO | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-AQGR | 20 (40 μL) | 200 μL |
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| NIPBL-ARNTL2-20-AQAQ | 20 (40 μL) | 200 μL |
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NIPBL Gene Summary
This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: NIPBL, Cohesin Loading Factor
Chromosome: CHR5: 36876860 -37065921
Locus: 5p13.2
ARNTL2 Gene Summary
This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
Gene Name: Aryl Hydrocarbon Receptor Nuclear Translocator Like 2
Chromosome: CHR12: 27485987 -27573466
Locus: 12p11.23
Gene Diseases
The NIPBL ARNTL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Rectum Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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