NFX1-NOL6 Fusion FISH Probe
The NFX1-NOL6 Fusion FISH Probe is used to confirm a fusion of the NFX1 and NOL6 genes. The fusion of the NFX1 and NOL6 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NFX1-NOL6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-RERE | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-REOR | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-REGO | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-REGR | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-REAQ | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-ORRE | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-OROR | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-ORGO | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-ORAQ | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-GORE | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-GOOR | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-GOGO | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-GOGR | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-GOAQ | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-GRRE | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-GROR | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-GRGO | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-GRGR | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-GRAQ | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-AQRE | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-AQOR | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-AQGO | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-AQGR | 20 (40 μL) | 200 μL |
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| NFX1-NOL6-20-AQAQ | 20 (40 μL) | 200 μL |
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NFX1 Gene Summary
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear Transcription Factor, X-box Binding 1
Chromosome: CHR9: 33290417 -33371155
Locus: 9p13.3
NOL6 Gene Summary
The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Nucleolar Protein 6
Chromosome: CHR9: 33461350 -33473941
Locus: 9p13.3
Gene Diseases
The NFX1 NOL6 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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