NFX1-DNAJA1 Fusion FISH Probe
The NFX1-DNAJA1 Fusion FISH Probe is used to confirm a fusion of the NFX1 and DNAJA1 genes. The fusion of the NFX1 and DNAJA1 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NFX1-DNAJA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-RERE | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-REOR | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-REGO | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-REGR | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-REAQ | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-ORRE | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-OROR | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-ORGO | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-GORE | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-GOOR | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-GOGO | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-GOGR | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-GRRE | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-GROR | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-GRGO | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-GRGR | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-AQRE | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-AQOR | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-AQGO | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-AQGR | 20 (40 μL) | 200 μL |
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| NFX1-DNAJA1-20-AQAQ | 20 (40 μL) | 200 μL |
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DNAJA1 Gene Summary
This gene encodes a member of the DnaJ family of proteins, which act as heat shock protein 70 cochaperones. Heat shock proteins facilitate protein folding, trafficking, prevention of aggregation, and proteolytic degradation. Members of this family are characterized by a highly conserved N-terminal J domain, a glycine/phenylalanine-rich region, four CxxCxGxG zinc finger repeats, and a C-terminal substrate-binding domain. The J domain mediates the interaction with heat shock protein 70 to recruit substrates and regulate ATP hydrolysis activity. In humans, this gene has been implicated in positive regulation of virus replication through co-option by the influenza A virus. Several pseudogenes of this gene are found on other chromosomes. [provided by RefSeq, Sep 2015]
Gene Name: DnaJ Heat Shock Protein Family (Hsp40) Member A1
Chromosome: CHR9: 33025208 -33039062
Locus: 9p21.1
NFX1 Gene Summary
MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear Transcription Factor, X-box Binding 1
Chromosome: CHR9: 33290417 -33371155
Locus: 9p13.3
Gene Diseases
The NFX1 DNAJA1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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