NFKBIE-FBXO9 Fusion FISH Probe
The NFKBIE-FBXO9 Fusion FISH Probe is used to confirm a fusion of the NFKBIE and FBXO9 genes. The fusion of the NFKBIE and FBXO9 genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NFKBIE-FBXO9-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-RERE | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-REOR | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-REGO | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-REGR | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-REAQ | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-ORRE | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-OROR | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-ORGO | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-ORAQ | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-GORE | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-GOOR | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-GOGO | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-GOGR | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-GOAQ | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-GRRE | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-GROR | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-GRGO | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-GRGR | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-GRAQ | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-AQRE | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-AQOR | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-AQGO | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-AQGR | 20 (40 μL) | 200 μL |
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| NFKBIE-FBXO9-20-AQAQ | 20 (40 μL) | 200 μL |
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NFKBIE Gene Summary
The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011]
Gene Name: NFKB Inhibitor Epsilon
Chromosome: CHR6: 44225902 -44233525
Locus: 6p21.1
FBXO9 Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus. [provided by RefSeq, Jul 2008]
Gene Name: F-box Protein 9
Chromosome: CHR6: 52929795 -52965670
Locus: 6p12.1
Gene Diseases
The NFKBIE FBXO9 Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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