NFKB2-GBF1 Fusion FISH Probe
The NFKB2-GBF1 Fusion FISH Probe is used to confirm a fusion of the NFKB2 and GBF1 genes. The fusion of the NFKB2 and GBF1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NFKB2-GBF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-RERE | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-REOR | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-REGO | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-REGR | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-REAQ | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-ORRE | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-OROR | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-ORGO | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-GORE | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-GOOR | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-GOGO | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-GOGR | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-GRRE | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-GROR | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-GRGO | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-GRGR | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-AQRE | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-AQOR | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-AQGO | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-AQGR | 20 (40 μL) | 200 μL |
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| NFKB2-GBF1-20-AQAQ | 20 (40 μL) | 200 μL |
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NFKB2 Gene Summary
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Gene Name: Nuclear Factor Kappa B Subunit 2
Chromosome: CHR10: 104154228 -104162281
Locus: 10q24.32
GBF1 Gene Summary
This gene encodes a member of the Sec7 domain family. The encoded protein is a guanine nucleotide exchange factor that regulates the recruitment of proteins to membranes by mediating GDP to GTP exchange. The encoded protein is localized to the Golgi apparatus and plays a role in vesicular trafficking by activating ADP ribosylation factor 1. The encoded protein has also been identified as an important host factor for viral replication. Multiple transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Name: Golgi Brefeldin A Resistant Guanine Nucleotide Exchange Factor 1
Chromosome: CHR10: 104005254 -104142656
Locus: 10q24.32
Gene Diseases
The NFKB2 GBF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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