NFKB1-LHFPL3 Fusion FISH Probe
The NFKB1-LHFPL3 Fusion FISH Probe is used to confirm a fusion of the NFKB1 and LHFPL3 genes. The fusion of the NFKB1 and LHFPL3 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NFKB1-LHFPL3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-RERE | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-REOR | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-REGO | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-REGR | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-REAQ | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-ORRE | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-OROR | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-ORGO | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-ORAQ | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-GORE | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-GOOR | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-GOGO | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-GOGR | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-GOAQ | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-GRRE | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-GROR | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-GRGO | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-GRGR | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-GRAQ | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-AQRE | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-AQOR | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-AQGO | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-AQGR | 20 (40 μL) | 200 μL |
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| NFKB1-LHFPL3-20-AQAQ | 20 (40 μL) | 200 μL |
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NFKB1 Gene Summary
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Feb 2016]
Gene Name: Nuclear Factor Kappa B Subunit 1
Chromosome: CHR4: 103422485 -103538459
Locus: 4q24
LHFPL3 Gene Summary
This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. Mutations in one LHFP-like gene result in deafness in humans and mice, and a second LHFP-like gene is fused to a high-mobility group gene in a translocation-associated lipoma. A partial gene fragment named LHFPL4 corresponds to a portion of the first exon of this gene. [provided by RefSeq, Jul 2008]
Gene Name: LHFPL Tetraspan Subfamily Member 3
Chromosome: CHR7: 103969103 -104549003
Locus: 7q22.2-q22.3
Gene Diseases
The NFKB1 LHFPL3 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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