NFIX-GCDH Fusion FISH Probe
The NFIX-GCDH Fusion FISH Probe is used to confirm a fusion of the NFIX and GCDH genes. The fusion of the NFIX and GCDH genes has been associated with Lung Adenocarcinoma, and Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NFIX-GCDH-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-RERE | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-REOR | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-REGO | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-REGR | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-REAQ | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-ORRE | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-OROR | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-ORGO | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-ORAQ | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-GORE | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-GOOR | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-GOGO | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-GOGR | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-GOAQ | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-GRRE | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-GROR | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-GRGO | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-GRGR | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-GRAQ | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-AQRE | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-AQOR | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-AQGO | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-AQGR | 20 (40 μL) | 200 μL |
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| NFIX-GCDH-20-AQAQ | 20 (40 μL) | 200 μL |
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GCDH Gene Summary
The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Mutations in this gene result in the metabolic disorder glutaric aciduria type 1, which is also known as glutaric acidemia type I. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 12. [provided by RefSeq, Mar 2013]
Gene Name: Glutaryl-CoA Dehydrogenase
Chromosome: CHR19: 13001973 -13010783
Locus: 19p13.13
NFIX Gene Summary
The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
Gene Name: Nuclear Factor I X
Chromosome: CHR19: 13106583 -13209610
Locus: 19p13.13
Gene Diseases
The NFIX GCDH Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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