NFIX-DOCK6 Fusion FISH Probe
The NFIX-DOCK6 Fusion FISH Probe is used to confirm a fusion of the NFIX and DOCK6 genes. The fusion of the NFIX and DOCK6 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NFIX-DOCK6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-RERE | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-REOR | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-REGO | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-REGR | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-REAQ | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-ORRE | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-OROR | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-ORGO | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-ORAQ | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-GORE | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-GOOR | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-GOGO | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-GOGR | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-GOAQ | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-GRRE | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-GROR | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-GRGO | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-GRGR | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-GRAQ | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-AQRE | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-AQOR | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-AQGO | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-AQGR | 20 (40 μL) | 200 μL |
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| NFIX-DOCK6-20-AQAQ | 20 (40 μL) | 200 μL |
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NFIX Gene Summary
The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
Gene Name: Nuclear Factor I X
Chromosome: CHR19: 13106583 -13209610
Locus: 19p13.13
DOCK6 Gene Summary
This gene encodes a member of the dedicator of cytokinesis (DOCK) family of atypical guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with small GTPases and are components of intracellular signaling networks. The encoded protein is a group C DOCK protein and plays a role in actin cytoskeletal reorganization by activating the Rho GTPases Cdc42 and Rac1. Mutations in this gene are associated with Adams-Oliver syndrome 2. [provided by RefSeq, Dec 2011]
Gene Name: Dedicator Of Cytokinesis 6
Chromosome: CHR19: 11309970 -11373157
Locus: 19p13.2
Gene Diseases
The NFIX DOCK6 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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