NFIB-FREM1 Fusion FISH Probe
The NFIB-FREM1 Fusion FISH Probe is used to confirm a fusion of the NFIB and FREM1 genes. The fusion of the NFIB and FREM1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NFIB-FREM1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-RERE | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-REOR | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-REGO | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-REGR | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-REAQ | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-ORRE | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-OROR | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-ORGO | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-GORE | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-GOOR | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-GOGO | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-GOGR | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-GRRE | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-GROR | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-GRGO | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-GRGR | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-AQRE | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-AQOR | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-AQGO | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-AQGR | 20 (40 μL) | 200 μL |
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| NFIB-FREM1-20-AQAQ | 20 (40 μL) | 200 μL |
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NFIB Gene Summary
The Nuclear Factor I B (NFIB) gene is located on chr9 :14081841-14398982 at 9p23-p22.3.
Gene Name: Nuclear Factor I B
Chromosome: CHR9: 14081841 -14398982
Locus: 9p23-p22.3
FREM1 Gene Summary
This gene encodes a basement membrane protein that may play a role in craniofacial and renal development. Mutations in this gene have been associated with bifid nose with or without anorectal and renal anomalies. Alternatively spliced transcript variants encoding different isoforms have been described. PubMed ID 19940113 describes one such variant that initiates transcription within a distinct, internal exon; the resulting shorter isoform (named Toll-like/interleukin-1 receptor regulator, TILRR) is suggested to be a co-receptor of the interleukin 1 receptor family and may regulate receptor function and Toll-like receptor/interleukin 1 receptor signal transduction, contributing to the control of inflammatory response activation. [provided by RefSeq, Apr 2011]
Gene Name: FRAS1 Related Extracellular Matrix 1
Chromosome: CHR9: 14734663 -14910993
Locus: 9p22.3
Gene Diseases
The NFIB FREM1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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