NFE2L2-PDE11A Fusion FISH Probe
The NFE2L2-PDE11A Fusion FISH Probe is used to confirm a fusion of the NFE2L2 and PDE11A genes. The fusion of the NFE2L2 and PDE11A genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NFE2L2-PDE11A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-RERE | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-REOR | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-REGO | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-REGR | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-REAQ | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-ORRE | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-OROR | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-ORGO | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-ORAQ | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-GORE | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-GOOR | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-GOGO | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-GOGR | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-GOAQ | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-GRRE | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-GROR | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-GRGO | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-GRGR | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-GRAQ | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-AQRE | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-AQOR | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-AQGO | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-AQGR | 20 (40 μL) | 200 μL |
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| NFE2L2-PDE11A-20-AQAQ | 20 (40 μL) | 200 μL |
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NFE2L2 Gene Summary
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]
Gene Name: Nuclear Factor, Erythroid 2 Like 2
Chromosome: CHR2: 178095032 -178129859
Locus: 2q31.2
PDE11A Gene Summary
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Phosphodiesterase 11A
Chromosome: CHR2: 178487976 -178973066
Locus: 2q31.2
Gene Diseases
The NFE2L2 PDE11A Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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