NFATC2-DOK5 Fusion FISH Probe
The NFATC2-DOK5 Fusion FISH Probe is used to confirm a fusion of the NFATC2 and DOK5 genes. The fusion of the NFATC2 and DOK5 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NFATC2-DOK5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-RERE | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-REOR | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-REGO | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-REGR | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-REAQ | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-ORRE | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-OROR | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-ORGO | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-ORAQ | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-GORE | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-GOOR | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-GOGO | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-GOGR | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-GOAQ | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-GRRE | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-GROR | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-GRGO | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-GRGR | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-GRAQ | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-AQRE | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-AQOR | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-AQGO | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-AQGR | 20 (40 μL) | 200 μL |
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| NFATC2-DOK5-20-AQAQ | 20 (40 μL) | 200 μL |
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NFATC2 Gene Summary
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012]
Gene Name: Nuclear Factor Of Activated T-cells 2
Chromosome: CHR20: 50007764 -50179168
Locus: 20q13.2
DOK5 Gene Summary
The protein encoded by this gene is a member of the DOK family of membrane proteins, which are adapter proteins involved in signal transduction. The encoded protein interacts with phosphorylated receptor tyrosine kinases to mediate neurite outgrowth and activation of the MAP kinase pathway. Unlike other DOK family proteins, this protein does not interact with RASGAP. This protein is up-regulated in patients with systemic sclerosis and is associated with fibrosis induced by insulin-like growth factor binding protein 5. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Gene Name: Docking Protein 5
Chromosome: CHR20: 53092265 -53267710
Locus: 20q13.2
Gene Diseases
The NFATC2 DOK5 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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