NFAT5-VPS4A Fusion FISH Probe
The NFAT5-VPS4A Fusion FISH Probe is used to confirm a fusion of the NFAT5 and VPS4A genes. The fusion of the NFAT5 and VPS4A genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NFAT5-VPS4A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-RERE | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-REOR | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-REGO | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-REGR | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-REAQ | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-ORRE | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-OROR | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-ORGO | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-ORAQ | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-GORE | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-GOOR | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-GOGO | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-GOGR | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-GOAQ | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-GRRE | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-GROR | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-GRGO | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-GRGR | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-GRAQ | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-AQRE | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-AQOR | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-AQGO | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-AQGR | 20 (40 μL) | 200 μL |
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| NFAT5-VPS4A-20-AQAQ | 20 (40 μL) | 200 μL |
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NFAT5 Gene Summary
The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear Factor Of Activated T-cells 5
Chromosome: CHR16: 69599868 -69738569
Locus: 16q22.1
VPS4A Gene Summary
The protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. The mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be really an yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 16; the gene for the other resides on chromosome 18. [provided by RefSeq, Jul 2008]
Gene Name: Vacuolar Protein Sorting 4 Homolog A
Chromosome: CHR16: 69345286 -69358946
Locus: 16q22.1
Gene Diseases
The NFAT5 VPS4A Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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