NFAT5-NOB1 Fusion FISH Probe
The NFAT5-NOB1 Fusion FISH Probe is used to confirm a fusion of the NFAT5 and NOB1 genes. The fusion of the NFAT5 and NOB1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NFAT5-NOB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-RERE | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-REOR | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-REGO | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-REGR | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-REAQ | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-ORRE | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-OROR | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-ORGO | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-GORE | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-GOOR | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-GOGO | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-GOGR | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-GRRE | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-GROR | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-GRGO | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-GRGR | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-AQRE | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-AQOR | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-AQGO | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-AQGR | 20 (40 μL) | 200 μL |
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| NFAT5-NOB1-20-AQAQ | 20 (40 μL) | 200 μL |
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NFAT5 Gene Summary
The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear Factor Of Activated T-cells 5
Chromosome: CHR16: 69599868 -69738569
Locus: 16q22.1
NOB1 Gene Summary
In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).[supplied by OMIM, Nov 2010]
Gene Name: NIN1/PSMD8 Binding Protein 1 Homolog
Chromosome: CHR16: 69775773 -69788829
Locus: 16q22.1
Gene Diseases
The NFAT5 NOB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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