NFAT5-CDH3 Fusion FISH Probe
The NFAT5-CDH3 Fusion FISH Probe is used to confirm a fusion of the NFAT5 and CDH3 genes. The fusion of the NFAT5 and CDH3 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NFAT5-CDH3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-RERE | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-REOR | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-REGO | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-REGR | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-REAQ | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-ORRE | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-OROR | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-ORGO | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-ORAQ | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-GORE | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-GOOR | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-GOGO | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-GOGR | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-GOAQ | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-GRRE | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-GROR | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-GRGO | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-GRGR | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-GRAQ | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-AQRE | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-AQOR | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-AQGO | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-AQGR | 20 (40 μL) | 200 μL |
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| NFAT5-CDH3-20-AQAQ | 20 (40 μL) | 200 μL |
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CDH3 Gene Summary
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene are associated with hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome (EEMS). [provided by RefSeq, Nov 2015]
Gene Name: Cadherin 3
Chromosome: CHR16: 68678150 -68732957
Locus: 16q22.1
NFAT5 Gene Summary
The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear Factor Of Activated T-cells 5
Chromosome: CHR16: 69599868 -69738569
Locus: 16q22.1
Gene Diseases
The NFAT5 CDH3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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