NFASC-RTN3 Fusion FISH Probe
The NFASC-RTN3 Fusion FISH Probe is used to confirm a fusion of the NFASC and RTN3 genes. The fusion of the NFASC and RTN3 genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NFASC-RTN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-RERE | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-REOR | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-REGO | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-REGR | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-REAQ | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-ORRE | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-OROR | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-ORGO | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-GORE | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-GOOR | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-GOGO | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-GOGR | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-GRRE | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-GROR | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-GRGO | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-GRGR | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-AQRE | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-AQOR | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-AQGO | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-AQGR | 20 (40 μL) | 200 μL |
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| NFASC-RTN3-20-AQAQ | 20 (40 μL) | 200 μL |
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RTN3 Gene Summary
This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]
Gene Name: Reticulon 3
Chromosome: CHR11: 63448921 -63527363
Locus: 11q13.1
NFASC Gene Summary
This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]
Gene Name: Neurofascin
Chromosome: CHR1: 204797781 -204991950
Locus: 1q32.1
Gene Diseases
The NFASC RTN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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