NFASC-PRELP Fusion FISH Probe
The NFASC-PRELP Fusion FISH Probe is used to confirm a fusion of the NFASC and PRELP genes. The fusion of the NFASC and PRELP genes has been associated with Glioblastoma Multiforme, and Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NFASC-PRELP-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-RERE | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-REOR | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-REGO | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-REGR | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-REAQ | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-ORRE | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-OROR | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-ORGO | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-ORAQ | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-GORE | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-GOOR | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-GOGO | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-GOGR | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-GOAQ | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-GRRE | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-GROR | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-GRGO | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-GRGR | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-GRAQ | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-AQRE | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-AQOR | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-AQGO | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-AQGR | 20 (40 μL) | 200 μL |
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| NFASC-PRELP-20-AQAQ | 20 (40 μL) | 200 μL |
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PRELP Gene Summary
The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Gene Name: Proline And Arginine Rich End Leucine Rich Repeat Protein
Chromosome: CHR1: 203444882 -203460479
Locus: 1q32.1
NFASC Gene Summary
This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]
Gene Name: Neurofascin
Chromosome: CHR1: 204797781 -204991950
Locus: 1q32.1
Gene Diseases
The NFASC PRELP Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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