NFASC-LRRN2 Fusion FISH Probe
The NFASC-LRRN2 Fusion FISH Probe is used to confirm a fusion of the NFASC and LRRN2 genes. The fusion of the NFASC and LRRN2 genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NFASC-LRRN2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-RERE | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-REOR | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-REGO | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-REGR | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-REAQ | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-ORRE | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-OROR | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-ORGO | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-ORAQ | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-GORE | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-GOOR | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-GOGO | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-GOGR | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-GOAQ | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-GRRE | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-GROR | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-GRGO | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-GRGR | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-GRAQ | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-AQRE | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-AQOR | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-AQGO | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-AQGR | 20 (40 μL) | 200 μL |
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| NFASC-LRRN2-20-AQAQ | 20 (40 μL) | 200 μL |
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LRRN2 Gene Summary
The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Leucine Rich Repeat Neuronal 2
Chromosome: CHR1: 204586302 -204654597
Locus: 1q32.1
NFASC Gene Summary
This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]
Gene Name: Neurofascin
Chromosome: CHR1: 204797781 -204991950
Locus: 1q32.1
Gene Diseases
The NFASC LRRN2 Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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