NF2-PIAS1 Fusion FISH Probe
The NF2-PIAS1 Fusion FISH Probe is used to confirm a fusion of the NF2 and PIAS1 genes. The fusion of the NF2 and PIAS1 genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NF2-PIAS1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-RERE | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-REOR | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-REGO | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-REGR | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-REAQ | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-ORRE | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-OROR | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-ORGO | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-GORE | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-GOOR | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-GOGO | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-GOGR | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-GRRE | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-GROR | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-GRGO | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-GRGR | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-AQRE | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-AQOR | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-AQGO | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-AQGR | 20 (40 μL) | 200 μL |
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| NF2-PIAS1-20-AQAQ | 20 (40 μL) | 200 μL |
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NF2 Gene Summary
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008]
Gene Name: Neurofibromin 2
Chromosome: CHR22: 29999544 -30094589
Locus: 22q12.2
PIAS1 Gene Summary
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Gene Name: Protein Inhibitor Of Activated STAT 1
Chromosome: CHR15: 68346571 -68480404
Locus: 15q23
Gene Diseases
The NF2 PIAS1 Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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