NF2-GRAP2 Fusion FISH Probe
The NF2-GRAP2 Fusion FISH Probe is used to confirm a fusion of the NF2 and GRAP2 genes. The fusion of the NF2 and GRAP2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NF2-GRAP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-RERE | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-REOR | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-REGO | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-REGR | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-REAQ | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-ORRE | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-OROR | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-ORGO | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-GORE | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-GOOR | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-GOGO | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-GOGR | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-GRRE | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-GROR | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-GRGO | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-GRGR | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-AQRE | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-AQOR | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-AQGO | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-AQGR | 20 (40 μL) | 200 μL |
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| NF2-GRAP2-20-AQAQ | 20 (40 μL) | 200 μL |
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NF2 Gene Summary
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008]
Gene Name: Neurofibromin 2
Chromosome: CHR22: 29999544 -30094589
Locus: 22q12.2
GRAP2 Gene Summary
This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Gene Name: GRB2-related Adaptor Protein 2
Chromosome: CHR22: 40297085 -40367384
Locus: 22q13.1
Gene Diseases
The NF2 GRAP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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