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NF1-TPMT Fusion FISH Probe

The NF1-TPMT Fusion FISH Probe is used to confirm a fusion of the NF1 and TPMT genes. The fusion of the NF1 and TPMT genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
NF1-TPMT-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
NF1-TPMT-20-RERE 20 (40 μL) 200 μL
NF1-TPMT-20-REOR 20 (40 μL) 200 μL
NF1-TPMT-20-REGO 20 (40 μL) 200 μL
NF1-TPMT-20-REGR 20 (40 μL) 200 μL
NF1-TPMT-20-REAQ 20 (40 μL) 200 μL
NF1-TPMT-20-ORRE 20 (40 μL) 200 μL
NF1-TPMT-20-OROR 20 (40 μL) 200 μL
NF1-TPMT-20-ORGO 20 (40 μL) 200 μL
NF1-TPMT-20-ORAQ 20 (40 μL) 200 μL
NF1-TPMT-20-GORE 20 (40 μL) 200 μL
NF1-TPMT-20-GOOR 20 (40 μL) 200 μL
NF1-TPMT-20-GOGO 20 (40 μL) 200 μL
NF1-TPMT-20-GOGR 20 (40 μL) 200 μL
NF1-TPMT-20-GOAQ 20 (40 μL) 200 μL
NF1-TPMT-20-GRRE 20 (40 μL) 200 μL
NF1-TPMT-20-GROR 20 (40 μL) 200 μL
NF1-TPMT-20-GRGO 20 (40 μL) 200 μL
NF1-TPMT-20-GRGR 20 (40 μL) 200 μL
NF1-TPMT-20-GRAQ 20 (40 μL) 200 μL
NF1-TPMT-20-AQRE 20 (40 μL) 200 μL
NF1-TPMT-20-AQOR 20 (40 μL) 200 μL
NF1-TPMT-20-AQGO 20 (40 μL) 200 μL
NF1-TPMT-20-AQGR 20 (40 μL) 200 μL
NF1-TPMT-20-AQAQ 20 (40 μL) 200 μL

NF1 Gene Summary

This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008]

Gene Name: Neurofibromin 1

Chromosome: CHR17: 29421944 -29704695

Locus: 17q11.2

TPMT Gene Summary

This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]

Gene Name: Thiopurine S-methyltransferase

Chromosome: CHR6: 18128544 -18155374

Locus: 6p22.3

Gene Diseases

The NF1 TPMT Fusion has been associated with the following diseases:

Disease Name
Ovarian Serous Cystadenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.