NF1-TPMT Fusion FISH Probe
The NF1-TPMT Fusion FISH Probe is used to confirm a fusion of the NF1 and TPMT genes. The fusion of the NF1 and TPMT genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NF1-TPMT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-RERE | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-REOR | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-REGO | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-REGR | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-REAQ | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-ORRE | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-OROR | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-ORGO | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-ORAQ | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-GORE | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-GOOR | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-GOGO | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-GOGR | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-GOAQ | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-GRRE | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-GROR | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-GRGO | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-GRGR | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-GRAQ | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-AQRE | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-AQOR | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-AQGO | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-AQGR | 20 (40 μL) | 200 μL |
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| NF1-TPMT-20-AQAQ | 20 (40 μL) | 200 μL |
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NF1 Gene Summary
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Neurofibromin 1
Chromosome: CHR17: 29421944 -29704695
Locus: 17q11.2
TPMT Gene Summary
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]
Gene Name: Thiopurine S-methyltransferase
Chromosome: CHR6: 18128544 -18155374
Locus: 6p22.3
Gene Diseases
The NF1 TPMT Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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