NF1-IKZF3 Fusion FISH Probe
The NF1-IKZF3 Fusion FISH Probe is used to confirm a fusion of the NF1 and IKZF3 genes. The fusion of the NF1 and IKZF3 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NF1-IKZF3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-RERE | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-REOR | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-REGO | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-REGR | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-REAQ | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-ORRE | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-OROR | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-ORGO | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-ORAQ | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-GORE | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-GOOR | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-GOGO | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-GOGR | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-GOAQ | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-GRRE | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-GROR | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-GRGO | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-GRGR | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-GRAQ | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-AQRE | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-AQOR | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-AQGO | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-AQGR | 20 (40 μL) | 200 μL |
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| NF1-IKZF3-20-AQAQ | 20 (40 μL) | 200 μL |
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NF1 Gene Summary
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Neurofibromin 1
Chromosome: CHR17: 29421944 -29704695
Locus: 17q11.2
IKZF3 Gene Summary
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]
Gene Name: IKAROS Family Zinc Finger 3
Chromosome: CHR17: 37921198 -38020441
Locus: 17q12-q21.1
Gene Diseases
The NF1 IKZF3 Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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