NF1-CLTC Fusion FISH Probe
The NF1-CLTC Fusion FISH Probe is used to confirm a fusion of the NF1 and CLTC genes. The fusion of the NF1 and CLTC genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NF1-CLTC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-RERE | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-REOR | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-REGO | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-REGR | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-REAQ | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-ORRE | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-OROR | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-ORGO | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-ORAQ | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-GORE | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-GOOR | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-GOGO | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-GOGR | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-GOAQ | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-GRRE | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-GROR | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-GRGO | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-GRGR | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-GRAQ | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-AQRE | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-AQOR | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-AQGO | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-AQGR | 20 (40 μL) | 200 μL |
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| NF1-CLTC-20-AQAQ | 20 (40 μL) | 200 μL |
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CLTC Gene Summary
Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains. [provided by RefSeq, Jul 2008]
Gene Name: Clathrin Heavy Chain
Chromosome: CHR17: 57697049 -57774317
Locus: 17q23.1
NF1 Gene Summary
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Neurofibromin 1
Chromosome: CHR17: 29421944 -29704695
Locus: 17q11.2
Gene Diseases
The NF1 CLTC Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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