NF1-CACNA1G Fusion FISH Probe
The NF1-CACNA1G Fusion FISH Probe is used to confirm a fusion of the NF1 and CACNA1G genes. The fusion of the NF1 and CACNA1G genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NF1-CACNA1G-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-RERE | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-REOR | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-REGO | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-REGR | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-REAQ | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-ORRE | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-OROR | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-ORGO | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-ORAQ | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-GORE | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-GOOR | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-GOGO | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-GOGR | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-GOAQ | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-GRRE | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-GROR | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-GRGO | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-GRGR | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-GRAQ | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-AQRE | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-AQOR | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-AQGO | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-AQGR | 20 (40 μL) | 200 μL |
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| NF1-CACNA1G-20-AQAQ | 20 (40 μL) | 200 μL |
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NF1 Gene Summary
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Neurofibromin 1
Chromosome: CHR17: 29421944 -29704695
Locus: 17q11.2
CACNA1G Gene Summary
Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2011]
Gene Name: Calcium Voltage-gated Channel Subunit Alpha1 G
Chromosome: CHR17: 48638448 -48704542
Locus: 17q21.33
Gene Diseases
The NF1 CACNA1G Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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