NF1-AGTR1 Fusion FISH Probe
The NF1-AGTR1 Fusion FISH Probe is used to confirm a fusion of the NF1 and AGTR1 genes. The fusion of the NF1 and AGTR1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NF1-AGTR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-RERE | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-REOR | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-REGO | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-REGR | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-REAQ | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-ORRE | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-OROR | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-ORGO | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-GORE | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-GOOR | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-GOGO | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-GOGR | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-GRRE | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-GROR | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-GRGO | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-GRGR | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-AQRE | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-AQOR | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-AQGO | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-AQGR | 20 (40 μL) | 200 μL |
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| NF1-AGTR1-20-AQAQ | 20 (40 μL) | 200 μL |
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AGTR1 Gene Summary
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]
Gene Name: Angiotensin II Receptor Type 1
Chromosome: CHR3: 148415657 -148460790
Locus: 3q24
NF1 Gene Summary
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Neurofibromin 1
Chromosome: CHR17: 29421944 -29704695
Locus: 17q11.2
Gene Diseases
The NF1 AGTR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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