NEK7-ATP2B4 Fusion FISH Probe
The NEK7-ATP2B4 Fusion FISH Probe is used to confirm a fusion of the NEK7 and ATP2B4 genes. The fusion of the NEK7 and ATP2B4 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NEK7-ATP2B4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-RERE | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-REOR | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-REGO | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-REGR | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-REAQ | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-ORRE | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-OROR | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-ORGO | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-ORAQ | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-GORE | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-GOOR | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-GOGO | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-GOGR | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-GOAQ | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-GRRE | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-GROR | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-GRGO | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-GRGR | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-GRAQ | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-AQRE | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-AQOR | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-AQGO | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-AQGR | 20 (40 μL) | 200 μL |
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| NEK7-ATP2B4-20-AQAQ | 20 (40 μL) | 200 μL |
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ATP2B4 Gene Summary
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: ATPase Plasma Membrane Ca2+ Transporting 4
Chromosome: CHR1: 203595914 -203713209
Locus: 1q32.1
NEK7 Gene Summary
NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.[supplied by OMIM, Jul 2002]
Gene Name: NIMA Related Kinase 7
Chromosome: CHR1: 198126107 -198291548
Locus: 1q31.3
Gene Diseases
The NEK7 ATP2B4 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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