NEK11-BDH1 Fusion FISH Probe
The NEK11-BDH1 Fusion FISH Probe is used to confirm a fusion of the NEK11 and BDH1 genes. The fusion of the NEK11 and BDH1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NEK11-BDH1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-RERE | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-REOR | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-REGO | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-REGR | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-REAQ | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-ORRE | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-OROR | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-ORGO | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-GORE | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-GOOR | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-GOGO | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-GOGR | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-GRRE | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-GROR | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-GRGO | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-GRGR | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-AQRE | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-AQOR | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-AQGO | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-AQGR | 20 (40 μL) | 200 μL |
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| NEK11-BDH1-20-AQAQ | 20 (40 μL) | 200 μL |
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BDH1 Gene Summary
This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and (R)-3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Gene Name: 3-hydroxybutyrate Dehydrogenase 1
Chromosome: CHR3: 197236653 -197300194
Locus: 3q29
NEK11 Gene Summary
This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]
Gene Name: NIMA Related Kinase 11
Chromosome: CHR3: 130745693 -131069309
Locus: 3q22.1
Gene Diseases
The NEK11 BDH1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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