NEIL3-AGA Fusion FISH Probe
The NEIL3-AGA Fusion FISH Probe is used to confirm a fusion of the NEIL3 and AGA genes. The fusion of the NEIL3 and AGA genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NEIL3-AGA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-RERE | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-REOR | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-REGO | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-REGR | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-REAQ | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-ORRE | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-OROR | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-ORGO | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-ORAQ | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-GORE | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-GOOR | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-GOGO | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-GOGR | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-GOAQ | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-GRRE | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-GROR | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-GRGO | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-GRGR | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-GRAQ | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-AQRE | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-AQOR | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-AQGO | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-AQGR | 20 (40 μL) | 200 μL |
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| NEIL3-AGA-20-AQAQ | 20 (40 μL) | 200 μL |
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AGA Gene Summary
This gene encodes a member of the N-terminal nucleophile (Ntn) hydrolase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta chains that comprise the mature enzyme. This enzyme is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. Mutations in this gene are associated with the lysosomal storage disease aspartylglycosaminuria that results in progressive neurodegeneration. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is subject to proteolytic processing. [provided by RefSeq, Nov 2015]
Gene Name: Aspartylglucosaminidase
Chromosome: CHR4: 178351928 -178363657
Locus: 4q34.3
NEIL3 Gene Summary
NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008]
Gene Name: Nei Like DNA Glycosylase 3
Chromosome: CHR4: 178230990 -178284092
Locus: 4q34.3
Gene Diseases
The NEIL3 AGA Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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