NEIL2-GATA4 Fusion FISH Probe
The NEIL2-GATA4 Fusion FISH Probe is used to confirm a fusion of the NEIL2 and GATA4 genes. The fusion of the NEIL2 and GATA4 genes has been associated with Testicular Germ Cell Tumors. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NEIL2-GATA4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-RERE | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-REOR | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-REGO | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-REGR | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-REAQ | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-ORRE | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-OROR | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-ORGO | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-ORAQ | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-GORE | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-GOOR | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-GOGO | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-GOGR | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-GOAQ | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-GRRE | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-GROR | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-GRGO | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-GRGR | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-GRAQ | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-AQRE | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-AQOR | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-AQGO | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-AQGR | 20 (40 μL) | 200 μL |
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| NEIL2-GATA4-20-AQAQ | 20 (40 μL) | 200 μL |
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GATA4 Gene Summary
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Gene Name: GATA Binding Protein 4
Chromosome: CHR8: 11561716 -11617509
Locus: 8p23.1
NEIL2 Gene Summary
This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]
Gene Name: Nei Like DNA Glycosylase 2
Chromosome: CHR8: 11627171 -11644854
Locus: 8p23.1
Gene Diseases
The NEIL2 GATA4 Fusion has been associated with the following diseases:
| Disease Name |
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| Testicular Germ Cell Tumors |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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