NEDD9-DTNBP1 Fusion FISH Probe
The NEDD9-DTNBP1 Fusion FISH Probe is used to confirm a fusion of the NEDD9 and DTNBP1 genes. The fusion of the NEDD9 and DTNBP1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NEDD9-DTNBP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-RERE | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-REOR | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-REGO | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-REGR | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-REAQ | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-ORRE | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-OROR | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-ORGO | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-GORE | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-GOOR | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-GOGO | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-GOGR | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-GRRE | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-GROR | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-GRGO | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-GRGR | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-AQRE | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-AQOR | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-AQGO | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-AQGR | 20 (40 μL) | 200 μL |
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| NEDD9-DTNBP1-20-AQAQ | 20 (40 μL) | 200 μL |
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NEDD9 Gene Summary
The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Gene Name: Neural Precursor Cell Expressed, Developmentally Down-regulated 9
Chromosome: CHR6: 11183530 -11382581
Locus: 6p24.2
DTNBP1 Gene Summary
This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and binds to alpha- and beta-dystrobrevins, which are components of the dystrophin-associated protein complex (DPC). Mutations in this gene are associated with Hermansky-Pudlak syndrome type 7. This gene may also be associated with schizophrenia. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Dystrobrevin Binding Protein 1
Chromosome: CHR6: 15523031 -15663289
Locus: 6p22.3
Gene Diseases
The NEDD9 DTNBP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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