NEDD4L-MORC3 Fusion FISH Probe
The NEDD4L-MORC3 Fusion FISH Probe is used to confirm a fusion of the NEDD4L and MORC3 genes. The fusion of the NEDD4L and MORC3 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NEDD4L-MORC3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-RERE | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-REOR | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-REGO | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-REGR | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-REAQ | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-ORRE | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-OROR | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-ORGO | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-ORAQ | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-GORE | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-GOOR | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-GOGO | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-GOGR | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-GOAQ | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-GRRE | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-GROR | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-GRGO | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-GRGR | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-GRAQ | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-AQRE | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-AQOR | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-AQGO | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-AQGR | 20 (40 μL) | 200 μL |
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| NEDD4L-MORC3-20-AQAQ | 20 (40 μL) | 200 μL |
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NEDD4L Gene Summary
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Gene Name: Neural Precursor Cell Expressed, Developmentally Down-regulated 4-like, E3 Ubiquitin Protein Ligase
Chromosome: CHR18: 55711609 -56068772
Locus: 18q21.31
MORC3 Gene Summary
This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]
Gene Name: MORC Family CW-type Zinc Finger 3
Chromosome: CHR21: 37692486 -37748944
Locus: 21q22.12
Gene Diseases
The NEDD4L MORC3 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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