NEDD4L-IMMP2L Fusion FISH Probe
The NEDD4L-IMMP2L Fusion FISH Probe is used to confirm a fusion of the NEDD4L and IMMP2L genes. The fusion of the NEDD4L and IMMP2L genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NEDD4L-IMMP2L-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-RERE | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-REOR | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-REGO | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-REGR | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-REAQ | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-ORRE | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-OROR | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-ORGO | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-ORAQ | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-GORE | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-GOOR | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-GOGO | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-GOGR | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-GOAQ | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-GRRE | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-GROR | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-GRGO | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-GRGR | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-GRAQ | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-AQRE | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-AQOR | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-AQGO | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-AQGR | 20 (40 μL) | 200 μL |
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| NEDD4L-IMMP2L-20-AQAQ | 20 (40 μL) | 200 μL |
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NEDD4L Gene Summary
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Gene Name: Neural Precursor Cell Expressed, Developmentally Down-regulated 4-like, E3 Ubiquitin Protein Ligase
Chromosome: CHR18: 55711609 -56068772
Locus: 18q21.31
IMMP2L Gene Summary
This gene encodes a protein involved in processing the signal peptide sequences used to direct mitochondrial proteins to the mitochondria. The encoded protein resides in the mitochondria and is one of the necessary proteins for the catalytic activity of the mitochondrial inner membrane peptidase (IMP) complex. Two variants that encode the same protein have been described for this gene. [provided by RefSeq, Sep 2011]
Gene Name: Inner Mitochondrial Membrane Peptidase Subunit 2
Chromosome: CHR7: 110303109 -111202347
Locus: 7q31.1
Gene Diseases
The NEDD4L IMMP2L Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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