NEDD4L-BCL2 Fusion FISH Probe
The NEDD4L-BCL2 Fusion FISH Probe is used to confirm a fusion of the NEDD4L and BCL2 genes. The fusion of the NEDD4L and BCL2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NEDD4L-BCL2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-RERE | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-REOR | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-REGO | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-REGR | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-REAQ | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-ORRE | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-OROR | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-ORGO | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-ORAQ | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-GORE | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-GOOR | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-GOGO | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-GOGR | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-GOAQ | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-GRRE | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-GROR | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-GRGO | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-GRGR | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-GRAQ | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-AQRE | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-AQOR | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-AQGO | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-AQGR | 20 (40 μL) | 200 μL |
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| NEDD4L-BCL2-20-AQAQ | 20 (40 μL) | 200 μL |
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BCL2 Gene Summary
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Gene Name: BCL2, Apoptosis Regulator
Chromosome: CHR18: 60790578 -60986613
Locus: 18q21.33
NEDD4L Gene Summary
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Gene Name: Neural Precursor Cell Expressed, Developmentally Down-regulated 4-like, E3 Ubiquitin Protein Ligase
Chromosome: CHR18: 55711609 -56068772
Locus: 18q21.31
Gene Diseases
The NEDD4L BCL2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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