NDUFS7-STK11 Fusion FISH Probe
The NDUFS7-STK11 Fusion FISH Probe is used to confirm a fusion of the NDUFS7 and STK11 genes. The fusion of the NDUFS7 and STK11 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NDUFS7-STK11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-RERE | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-REOR | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-REGO | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-REGR | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-REAQ | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-ORRE | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-OROR | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-ORGO | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-ORAQ | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-GORE | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-GOOR | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-GOGO | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-GOGR | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-GOAQ | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-GRRE | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-GROR | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-GRGO | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-GRGR | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-GRAQ | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-AQRE | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-AQOR | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-AQGO | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-AQGR | 20 (40 μL) | 200 μL |
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| NDUFS7-STK11-20-AQAQ | 20 (40 μL) | 200 μL |
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STK11 Gene Summary
This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Name: Serine/threonine Kinase 11
Chromosome: CHR19: 1205797 -1228434
Locus: 19p13.3
NDUFS7 Gene Summary
This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory chain. This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. This complex functions in the transfer of electrons from NADH to the respiratory chain, and ubiquinone is believed to be the immediate electron acceptor for the enzyme. Mutations in this gene cause Leigh syndrome due to mitochondrial complex I deficiency, a severe neurological disorder that results in bilaterally symmetrical necrotic lesions in subcortical brain regions. [provided by RefSeq, Jul 2008]
Gene Name: NADH:ubiquinone Oxidoreductase Core Subunit S7
Chromosome: CHR19: 1383882 -1395588
Locus: 19p13.3
Gene Diseases
The NDUFS7 STK11 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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