NDUFS4-GZMA Fusion FISH Probe
The NDUFS4-GZMA Fusion FISH Probe is used to confirm a fusion of the NDUFS4 and GZMA genes. The fusion of the NDUFS4 and GZMA genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NDUFS4-GZMA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-RERE | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-REOR | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-REGO | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-REGR | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-REAQ | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-ORRE | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-OROR | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-ORGO | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-ORAQ | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-GORE | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-GOOR | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-GOGO | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-GOGR | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-GOAQ | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-GRRE | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-GROR | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-GRGO | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-GRGR | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-GRAQ | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-AQRE | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-AQOR | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-AQGO | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-AQGR | 20 (40 μL) | 200 μL |
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| NDUFS4-GZMA-20-AQAQ | 20 (40 μL) | 200 μL |
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GZMA Gene Summary
Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008]
Gene Name: Granzyme A
Chromosome: CHR5: 54398473 -54406080
Locus: 5q11.2
NDUFS4 Gene Summary
This gene encodes an nuclear-encoded accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I, or NADH:ubiquinone oxidoreductase). Complex I removes electrons from NADH and passes them to the electron acceptor ubiquinone. Mutations in this gene can cause mitochondrial complex I deficiencies such as Leigh syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Gene Name: NADH:ubiquinone Oxidoreductase Subunit S4
Chromosome: CHR5: 52856464 -52979171
Locus: 5q11.2
Gene Diseases
The NDUFS4 GZMA Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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