NDRG1-MYC Fusion FISH Probe
The NDRG1-MYC Fusion FISH Probe is used to confirm a fusion of the NDRG1 and MYC genes. The fusion of the NDRG1 and MYC genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NDRG1-MYC-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-RERE | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-REOR | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-REGO | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-REGR | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-REAQ | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-ORRE | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-OROR | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-ORGO | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-ORAQ | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-GORE | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-GOOR | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-GOGO | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-GOGR | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-GOAQ | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-GRRE | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-GROR | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-GRGO | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-GRGR | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-GRAQ | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-AQRE | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-AQOR | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-AQGO | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-AQGR | 20 (40 μL) | 200 μL |
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| NDRG1-MYC-20-AQAQ | 20 (40 μL) | 200 μL |
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MYC Gene Summary
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]
Gene Name: MYC Proto-oncogene, BHLH Transcription Factor
Chromosome: CHR8: 128748314 -128753680
Locus: 8q24.21
NDRG1 Gene Summary
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Gene Name: N-myc Downstream Regulated 1
Chromosome: CHR8: 134249413 -134309547
Locus: 8q24.22
Gene Diseases
The NDRG1 MYC Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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