NDC80-PPP4R1 Fusion FISH Probe
The NDC80-PPP4R1 Fusion FISH Probe is used to confirm a fusion of the NDC80 and PPP4R1 genes. The fusion of the NDC80 and PPP4R1 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NDC80-PPP4R1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-RERE | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-REOR | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-REGO | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-REGR | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-REAQ | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-ORRE | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-OROR | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-ORGO | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-GORE | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-GOOR | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-GOGO | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-GOGR | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-GRRE | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-GROR | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-GRGO | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-GRGR | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-AQRE | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-AQOR | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-AQGO | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-AQGR | 20 (40 μL) | 200 μL |
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| NDC80-PPP4R1-20-AQAQ | 20 (40 μL) | 200 μL |
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PPP4R1 Gene Summary
This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Gene Name: Protein Phosphatase 4 Regulatory Subunit 1
Chromosome: CHR18: 9546791 -9614600
Locus: 18p11.22
NDC80 Gene Summary
This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]
Gene Name: NDC80, Kinetochore Complex Component
Chromosome: CHR18: 2571509 -2616634
Locus: 18p11.32
Gene Diseases
The NDC80 PPP4R1 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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