NCSTN-SREBF1 Fusion FISH Probe
The NCSTN-SREBF1 Fusion FISH Probe is used to confirm a fusion of the NCSTN and SREBF1 genes. The fusion of the NCSTN and SREBF1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NCSTN-SREBF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-RERE | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-REOR | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-REGO | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-REGR | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-REAQ | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-ORRE | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-OROR | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-ORGO | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-GORE | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-GOOR | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-GOGO | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-GOGR | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-GRRE | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-GROR | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-GRGO | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-GRGR | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-AQRE | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-AQOR | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-AQGO | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-AQGR | 20 (40 μL) | 200 μL |
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| NCSTN-SREBF1-20-AQAQ | 20 (40 μL) | 200 μL |
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SREBF1 Gene Summary
This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017]
Gene Name: Sterol Regulatory Element Binding Transcription Factor 1
Chromosome: CHR17: 17714662 -17740325
Locus: 17p11.2
NCSTN Gene Summary
This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Feb 2014]
Gene Name: Nicastrin
Chromosome: CHR1: 160313062 -160328742
Locus: 1q23.2
Gene Diseases
The NCSTN SREBF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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