NCOR1-HIC1 Fusion FISH Probe
The NCOR1-HIC1 Fusion FISH Probe is used to confirm a fusion of the NCOR1 and HIC1 genes. The fusion of the NCOR1 and HIC1 genes has been associated with Cholangiocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NCOR1-HIC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-RERE | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-REOR | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-REGO | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-REGR | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-REAQ | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-ORRE | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-OROR | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-ORGO | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-GORE | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-GOOR | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-GOGO | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-GOGR | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-GRRE | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-GROR | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-GRGO | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-GRGR | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-AQRE | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-AQOR | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-AQGO | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-AQGR | 20 (40 μL) | 200 μL |
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| NCOR1-HIC1-20-AQAQ | 20 (40 μL) | 200 μL |
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HIC1 Gene Summary
This gene functions as a growth regulatory and tumor repressor gene. Hypermethylation or deletion of the region of this gene have been associated with tumors and the contiguous-gene syndrome, Miller-Dieker syndrome. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Gene Name: HIC ZBTB Transcriptional Repressor 1
Chromosome: CHR17: 1958392 -1962981
Locus: 17p13.3
NCOR1 Gene Summary
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
Gene Name: Nuclear Receptor Corepressor 1
Chromosome: CHR17: 15933407 -16118874
Locus: 17p12-p11.2
Gene Diseases
The NCOR1 HIC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Cholangiocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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