NCOR1-FBXO3 Fusion FISH Probe
The NCOR1-FBXO3 Fusion FISH Probe is used to confirm a fusion of the NCOR1 and FBXO3 genes. The fusion of the NCOR1 and FBXO3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NCOR1-FBXO3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-RERE | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-REOR | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-REGO | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-REGR | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-REAQ | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-ORRE | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-OROR | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-ORGO | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-ORAQ | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-GORE | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-GOOR | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-GOGO | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-GOGR | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-GOAQ | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-GRRE | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-GROR | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-GRGO | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-GRGR | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-GRAQ | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-AQRE | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-AQOR | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-AQGO | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-AQGR | 20 (40 μL) | 200 μL |
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| NCOR1-FBXO3-20-AQAQ | 20 (40 μL) | 200 μL |
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NCOR1 Gene Summary
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
Gene Name: Nuclear Receptor Corepressor 1
Chromosome: CHR17: 15933407 -16118874
Locus: 17p12-p11.2
FBXO3 Gene Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3' end. [provided by RefSeq, Jul 2008]
Gene Name: F-box Protein 3
Chromosome: CHR11: 33762489 -33796071
Locus: 11p13
Gene Diseases
The NCOR1 FBXO3 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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