NCOR1-DPM1 Fusion FISH Probe
The NCOR1-DPM1 Fusion FISH Probe is used to confirm a fusion of the NCOR1 and DPM1 genes. The fusion of the NCOR1 and DPM1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NCOR1-DPM1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-RERE | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-REOR | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-REGO | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-REGR | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-REAQ | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-ORRE | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-OROR | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-ORGO | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-GORE | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-GOOR | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-GOGO | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-GOGR | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-GRRE | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-GROR | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-GRGO | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-GRGR | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-AQRE | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-AQOR | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-AQGO | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-AQGR | 20 (40 μL) | 200 μL |
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| NCOR1-DPM1-20-AQAQ | 20 (40 μL) | 200 μL |
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DPM1 Gene Summary
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Gene Name: Dolichyl-phosphate Mannosyltransferase Subunit 1, Catalytic
Chromosome: CHR20: 49551404 -49575060
Locus: 20q13.13
NCOR1 Gene Summary
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
Gene Name: Nuclear Receptor Corepressor 1
Chromosome: CHR17: 15933407 -16118874
Locus: 17p12-p11.2
Gene Diseases
The NCOR1 DPM1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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