NCOA3-PADI1 Fusion FISH Probe
The NCOA3-PADI1 Fusion FISH Probe is used to confirm a fusion of the NCOA3 and PADI1 genes. The fusion of the NCOA3 and PADI1 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NCOA3-PADI1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-RERE | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-REOR | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-REGO | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-REGR | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-REAQ | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-ORRE | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-OROR | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-ORGO | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-ORAQ | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-GORE | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-GOOR | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-GOGO | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-GOGR | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-GOAQ | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-GRRE | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-GROR | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-GRGO | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-GRGR | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-GRAQ | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-AQRE | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-AQOR | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-AQGO | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-AQGR | 20 (40 μL) | 200 μL |
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| NCOA3-PADI1-20-AQAQ | 20 (40 μL) | 200 μL |
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NCOA3 Gene Summary
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]
Gene Name: Nuclear Receptor Coactivator 3
Chromosome: CHR20: 46130600 -46285621
Locus: 20q13.12
PADI1 Gene Summary
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]
Gene Name: Peptidyl Arginine Deiminase 1
Chromosome: CHR1: 17531620 -17572501
Locus: 1p36.13
Gene Diseases
The NCOA3 PADI1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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