NCOA3-EYA2 Fusion FISH Probe
The NCOA3-EYA2 Fusion FISH Probe is used to confirm a fusion of the NCOA3 and EYA2 genes. The fusion of the NCOA3 and EYA2 genes has been associated with Ovarian Serous Cystadenocarcinoma, Lung Squamous Cell Carcinoma, Lung Adenocarcinoma, Uterine Corpus Endometrial Carcinoma, and Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| NCOA3-EYA2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-RERE | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-REOR | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-REGO | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-REGR | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-REAQ | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-ORRE | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-OROR | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-ORGO | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-ORAQ | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-GORE | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-GOOR | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-GOGO | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-GOGR | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-GOAQ | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-GRRE | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-GROR | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-GRGO | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-GRGR | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-GRAQ | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-AQRE | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-AQOR | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-AQGO | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-AQGR | 20 (40 μL) | 200 μL |
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| NCOA3-EYA2-20-AQAQ | 20 (40 μL) | 200 μL |
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EYA2 Gene Summary
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined. [provided by RefSeq, Jul 2009]
Gene Name: EYA Transcriptional Coactivator And Phosphatase 2
Chromosome: CHR20: 45523262 -45817492
Locus: 20q13.12
NCOA3 Gene Summary
The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]
Gene Name: Nuclear Receptor Coactivator 3
Chromosome: CHR20: 46130600 -46285621
Locus: 20q13.12
Gene Diseases
The NCOA3 EYA2 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
| Lung Squamous Cell Carcinoma |
| Lung Adenocarcinoma |
| Uterine Corpus Endometrial Carcinoma |
| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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